Clopidogrel selectively inhibits the binding of ADP to its platelet receptor mediated activation and subsequent AP of the glycoprotein IIb / IIIa, inhibiting platelet aggregation. The metabolism of clopidogrel is required to produce inhibition of platelet aggregation, but an active metabolite responsible for the activity of the drug has not been isolated. Clopidogrel also inhibited platelet aggregation induced by agonists other than than ADP by blocking the amplification of platelet activation induced by the PA released Clopidogrel did not inhibit phosphodiesterase activity buy generic plavix . The dose-dependent inhibition of platelet aggregation could be seen 2 hours after single oral doses of PLAVIX. Repeated doses of 75 mg PLAVIX per day inhibit platelet aggregation induced PA the first day, and the inhibition reaches steady state between day 3 and day 7. A steady state, the average inhibition level observed with a dose of 75 mg PLAVIX per day was between 40 percent and 60 percent. Platelet aggregation and bleeding time gradually return to baseline values after treatment is stopped, generally after about 5 days.
If the labels should be kept in energy drinks, says Storey, coffee coffee should also be required to label caffeine content.
The industry begs to differ, with a spokesman noting that most mainstream energy drinks contain the same amount of caffeine, or even less, you get a cup of coffee. If labels listing caffeine content energy drinks are required, they should also be kept on a coffee cafe, says Maureen Storey, Ph.D., a spokesman for the American Association of drinks. Energy Drink: Back Story