Compound with potent effects found by researchers from the biological clock

Longdaysin is the champion of the extent to which it can move the clock, said Kay, whose laboratory at UCSD have discovered compounds in previous studies that could change the biological clock, for several hours. We were really surprised to find out how you can slow the biological clock of this compound and still have a clock running.Theoretically, longdaysin or a compound, as it could be used to correct sleep disorders like sleep genetic syndrome familial affection peak, which is characterized by a clock that runs too fast, said Steve Kay, dean of UCSD’s Division of Science Biology, who led the research team that published its findings in the journal PLoS Biology. A compound that makes the clock slow down or speed can also be used to phase shift the clock -. In other words, bump, or turning the clock back, that will help your body recover when it’s jet lag or give a normal day-night cycle when it was thrown out of the phase shift.

The researchers demonstrated the dramatic effects of longdaysin lengthening the biological clocks of zebrafish larvae over 10 hours.

Called by scientists longdaysin, for its ability to significantly slow the biological clock, the new compound and the application of their method of screening for the discovery of other chemical changes could open the door to watch a series of new drugs for the treatment of severe sleep disorders or quickly recover from jet lag, the biological clock travelers who regularly travel across time zones.

We were really encouraged to see that when we added longdaysin of these zebra fish live, we have extended the biological clock and do not see any obvious deleterious effects, said Kay. This has shown us that our work and high speed assay accurately predicted how the compound works the biological clock of a live fish. The next thing to do is try this in a system of mammals.

Other co-authors of the document beyond Hirota and Schultz were Warren Lewis, Eric Zhang, Ghislain Breton and David Traver of UCSD, Jae Wook Lee of TSRI; Xianzhong Liu, Michael Garcia, Eric Peters of the Genomics Institute of the Novartis Foundation for Search and Pierre Etchegaray of the University of Massachusetts Medical School.

Once the group had isolated longdaysin Kay turned to organic chemicals in the laboratory of Peter Schultz, The Scripps Research Institute to characterize the molecule and to understand the mechanisms of how long the body clock. This analysis showed that three distinct protein kinases on the compound were responsible for the dramatic effect of longdaysin, one of which, CK1alpha, had been ignored by chronobiology researchers.

The study was funded by grants from the National Institutes of Health.

Longdaysin is not as strong as we would like, he adds. It will be a research tool.

The researchers then showed that longdaysin had the same effect of lengthening the biological clock in mice and tissue samples zebrafish larvae that carried the luciferase gene attached to their clock genes.

Patients hospitalized with pneumonia may be at risk of experiencing sudden cardiac arrest, often with little or no warning signs, according to a study by the University of Chicago Medical Center, under the auspices of the American Heart Association Get with the guidelines of the project.

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