The document, in addition to Pan, are Jianzhong Yu, Stephen Klusza Deng and Wu Min-Florida State University, and Zheng Yonggang Dong Jixin and at Johns Hopkins.In a series of experiments, scientists have manipulated Kibra role in a signaling network called the way of Hippo, which consists of different proteins work together as a braking system. Homologous components of the Hippo pathway in flight can be found in most animals, suggesting that this path can act as a global regulator to control the size of the organs, according Duojia Pan, Ph.D., professor of biology and molecular genetics at Johns Hopkins University School of Medicine and a researcher at the Howard Hughes Medical Institute
New experiences, Pan said, the investigation moved slowly and methodically to mount to find trigger Hippo, where it is believed that the key to the size of the control lies. Hippo-Kibra link may be a key to understanding and treating cancer, Pan says, because the cancer is literally a disease of uncontrolled growth.
This research was funded by grants from the National Institutes of Health.
The name, shortened words Kibra a combination of kidney and brain, is based on the first trial that has highlighted Kibra expressed in these two organs. Kibra role in memory performance in humans has already attracted interest.
Other studies measured the activity of human cells during the manipulation path Hippo Kibra humans and showed that as the fruit fly counterpart, human Kibra protein acts as a tumor suppressor that regulates the Hippo signaling.
Barrera works at the University of Toronto Hospital for Sick Children. The study is the cancer. Other survivors of childhood cancer
The discovery of Kibra you move an important step towards the identification of the initial signal that triggers the activation of Hippo, said Pan. We are making progress towards Hippo, indicating the cell surface, and I think we find this elusive signal along the way.
The Johns Hopkins University and Florida State teams have discovered, by studying the cells of the ovary Kibra and adult flies, using a technique called genetic control RNA interference to systematically disable each of the approximately 14,000 genes in the genome fly, one at a time, flying in cultured cells. They then analyzed the function of Kibra in the development of fly larvae. Each of the discs that develop specialized in the eyes of a fly begins with about 30 to 40 cells and increases of about a thousand times before stopping in the larval stage, making it ideal for the larvae to properly size the process in place, Pan he said.
These studies have been told that the way was not active in the absence Hippo Kibra