This study appears in the January issue of the Journal of Roentgenology.Researchers at Emory University in Atlanta, to recommend that progesterone (PROG), a natural hormone found in both males and females can protect damaged cells in the central and peripheral nervous system, be considered as a viable treatment option for trauma head, according to a clinical point of view published in the January issue of the Journal of Roentgenology.
“Given its relatively high safety profile, ease of administration, low cost and availability, PROG should be considered a viable treatment option – especially since, in the brain, then nothing else is available today,” said Stein .
PROG has recently been tested in two clinical trials of phase 2 and phase 3 will begin testing a NIH sponsored soon.
“Growing evidence indicates that post-traumatic administration of PROG in a variety of models of brain injury may have beneficial effects, resulting in substantial and lasting improvements in brain function. PROG gave both boys and girls can cross the blood-brain barrier and reduce (swelling) levels after head injury and in models of cerebral ischemia (restriction of blood supply), to significantly reduce the area of necrotic cell death and improved behavioral outcomes, and protect neurons downstream of the lesion that normally die “said Stein.
“Traumatic brain injury (TBI) is a major clinical problem in the United States and around the world,” said Donald G. Stein, Ph.D., author of the study. “TCC has received more attention recently due to its high incidence among soldiers wounded in combat in Iraq and Afghanistan. Current Ministry of Defense said that the statistics up to 30 percent wounded soldiers at Walter Reed Army Hospital has suffered a head injury seen, a discovery that spurred the interest of the government to develop a safe and effective treatment for this complex disease, “said Stein.